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Fredericks Research

What's New

Within this section, an overview of recently published studies across the multi-disciplinary health care arena, relating to the theme of supporting patients following invasive cardiovascular surgical procedures will be presented. Even though specific emphasis will be on highlighting evidence from randomized controlled trials, findings from studies using innovative designs will also be presented.


1.) Greve, H., & Pedersen, P. U. (2016). Improving sleep after open heart surgery-Effectiveness of nursing interventions. Journal of Nursing Education and Practice, 6(3), 15.


The aim of this study was to examine the effect of patients’ self-reported sleep quality following open heart surgery using a controlled intervention study. The treatment consisted of sleep anamneses and hygienic principles. No significant effect of the intervention was reported. However some effect was noted in increasing total sleep time, sleep efficiency, and sleep quality.


2.) Tully, P. J., Baumeister, H., Bennetts, J. S., Rice, G. D., & Baker, R. A. (2016). Depression screening after cardiac surgery: A six month longitudinal follow up for cardiac events, hospital readmissions, quality of life and mental health. International Journal of Cardiology, 206, 44-50.


Study objective was to report 6-month longitudinal outcomes of routine depression in cardiac patients. The Patient Health Questionnaire (PHQ) was used for routine depression screening on 481 patients. The patients identified as depressed were at increased risk of depressed mood, poorer quality of life, and were more likely to be initiated on antidepressants and anxiolytic at follow-up.


3.) Tully, P. J., Turnbull, D. A., Horowitz, J. D., Beltrame, J. F., Selkow, T., Baune, B. T., ... & Wittert, G. A. (2016). Cardiovascular Health in Anxiety or Mood Problems Study (CHAMPS): study protocol for a randomized controlled trial. Trials, 17(1), 18.


STUDY PROTOCOL -- The aim of the Cardiovascular Health in Anxiety or Mood Problems Study (CHAMPS) will be to determine the feasibility of a unified protocol (UP) for treatment of emotional disorders (e.g. self-reported anxiety, depression and quality of life symptoms) intervention in recently hospitalized patients with cardiovascular disease. A feasibility randomized, controlled trial with a single-center design was used with 50 participants. UP was delivered over 12 to 18 weeks.


4.) Konstantinidis, I., Nadkarni, G. N., Yacoub, R., Saha, A., Simoes, P., Parikh, C. R., & Coca, S. G. (2016). Representation of Patients With Kidney Disease in Trials of Cardiovascular Interventions: An Updated Systematic Review. JAMA internal medicine, 176(1), 121-124.

This investigator initiated prospective randomized double blind placebo controlled study was performed in 48 low risk coronary artery bypass graft patients. The intention of this trial was to determine the effectiveness of 2 g fibrinogen infused immediately before surgery, after induction of anesthesia, in reducing blood loss during the first 12 hours post-operatively. Findings suggests pre-operative supplementation with 2 g fibrinogen concentrate did not significantly influence post-operative bleeding.




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